Welcome To Taj Active Pharmaceuticals Ingredients & Chemicals (api) Taj Pharmaceuticals Limited (Manufacturers) India
    About Worldwide  |     FAQs    |    Careers    |        Media Center  |    Taj Pharmaceuticals  World   |    TAJ Group
    Taj Active Pharmaceuticals Ingredients & Chemicals (api) Taj Pharmaceuticals Limited

chemicals suppliers

      India              Latin America/ Caribbean            Africa & Middle East              Asia              Russia              Europe  

Active Pharmaceutical Ingredients  TAJ PHARMACEUTICALS LIMITED  

Home    API   Pharmaceuticals API List    Chemicals    Manufacturing     Product Development    Product Search    Agro Chemicals
  Custom Pharma Services      Contact Us

BP - British Pharmacopoeia CP - Chinese Pharmacopoeia EP - European Pharmacopoeia JP - Japanese Pharmacopoeia USP - United States Pharmacopoeia
***
Product exploitation, including development, sales and offer for sale are performed where permissible by patent law. This presentation is not and should not constitute as an offer for sale in territories where it is not permitted by law.

Domperidone Maleate manufacturers India exporter cas No. 99497-03-70 Domperidone Maleate  suppliers from india companies Pharmaceuticals Drug from India Largest manufacturer Top Domperidone Maleate import india Domperidone Maleate export india Domperidone Maleate buyer india Domperidone Maleate seller India IP BP USP EP Domperidone Maleate Raw material manufacturer india Domperidone Maleate dealers india Domperidone Maleate producer india Domperidone Maleate API Active pharmaceuticals ingradients  Purchase Cheap Lowest Price COA MSDS certificate of Analysis wholesalers india Domperidone Maleate suppliers india Domperidone Maleate trader Drug india Domperidone Maleate purchase india Domperidone Maleate structure Domperidone Maleate benefits Domperidone Maleate pharmacy and drugs review api Domperidone Maleate  active pharmaceutical ingredients suppliers pharmaceutical manufacturing pharmaceutical drugs pharmaceutical intermediates pharmaceutical chemicals pharmaceutical raw materials active pharmaceutical ingredients committee active pharmaceutical ingredients manufacturer construction chemicals manufacturers manufacturers of industrial chemicals chemicals suppliers chemicals Domperidone Maleate  offers chemicals wholesalers exporters chemicals specialty chemicals chemicals Domperidone Maleates indian chemical suppliers chemicals india company  Indian chemical manufacturers association chemical industries in India indian chemical company chemical factories india safety Domperidone Maleates manufacturers India plastic Domperidone Maleates manufacturers India definition of Domperidone Maleate Domperidone Maleate  synthesis Domperidone Maleate  salt effects of Domperidone Maleate clinical advantage of Domperidone Maleate polymorphs of Domperidone Maleate preparation of Domperidone Maleate efficacy of Domperidone Maleate beneficial effects of Domperidone Maleate determination and validation of Domperidone Maleate determination Domperidone Maleate Domperidone Maleate -Domperidone Maleate side effect of Domperidone Maleate polymorphs of Domperidone Maleate level of Domperidone Maleate Domperidone Maleate process for preparing Domperidone Maleate Domperidone Maleate mg process for Domperidone Maleate detailed info for Domperidone Maleate catalog Domperidone Maleate polymorphs of Domperidone Maleate dosage of Domperidone Maleate intermediate of Domperidone Maleate Domperidone Maleate powder supply Domperidone Maleate Taj Pharmaceuticals Limited.

 

 Taj Active Pharmaceuticals Ingredients & Chemicals

   Bulk Drugs Pharmaceuticals
   Chemicals
   Oseltamivir Phosphate
   Phenyl Propanolamine
   Phenylephrine
   Etafedrine
   Theophylline
   Tramadol
   Methylphenidate
   Morphine HCl
   Morphine sulphate
   Ephedrine (EPH)
   Pseudoephedrine hydrochloride
   Codeine base
   Codeine phosphate hemihydrate
   Zolpidem Tartrate
   Caffeine
   Gabapentin
   Gemcitabine
   Glimepiride
   Granisetron Hcl
   Ibandronate Sodium
   Imatinib Mesylate
   Irbesartan
   Irinotecan Hcl
   Isradipine
   Lamotrigine
   Lercanidipine Hcl
   Letrozole
   Losartan Potassium
   Loteprednol Etabonate
   Magnesium Valproate
   Meloxicam
   Memantine Hcl
   Mesalazine
   Metamizol Magnesium
   Metaxalone
   Metformin Hcl
   Metoprolol Tartrate
   Mifepristone
   Mirtazapine
   Modafinil
   Mometasone Furoate
   Naltrexone Hcl
   Netaglinide
   Octreotide Acetate
   Olanzapine
   Ondansetron Base
   Ondansetron Hcl
   Oxaliplatin
   Oxcarbazepine
   Oxethazaine
   Pamidronate Disodium
   Pentoxifylline
   Perindopril
   Pioglitazone
   PiroxicamBetacyclodextrine
   Raloxifene Hcl
   Repaglinide
   Rivastigmine Tartrate
   Ropinirole
   Sertraline Hcl
   Sodium Valproate
   Sildenafil Citrate
   Sumatriptan Succinate
   Temozolomide
   Terlipressin
   Testosterone
   Tiagabine Hcl
   Tizanidine Hcl
   Topiramate
   Tramadol Hcl
   Valproic Acid
   Venlafaxine Hcl
   Ziprasidone Hcl
   Zoledronic Acid
   Acenocoumarol
   Aluminium-magnesium-hydroxy-carbonate-hexahydrate
   Buprenorphine HCl
   Dihydrocodeine hydrogentartrate
   Ethylmorphine HCl
   Glibornuride
   Hydroxychloroquine sulphate
   Noroxymorphone
   Noscapine base
   Oxycodone
   Oxymorphone
   Phenobarbital acid
   Phenobarbital sodium
   Thebaine
   Pharmaceuticals API
   Alfuzosin
   Amlodipine Besylate
    Aripiprazole
   Atorvastatin Calcium
   Caffeine
   Candesartan Cilaxetil
   Cefdinir
   Cetirizine Dihydrochloride
   Ciprofloxacin HCl
   Dextromethorphan Base
   Diltiazem HCl
   Domperidone Base
   Domperidone Maleate
   Doxazosin Mesylate
   Duloxetine HCl
   Dutasteride
   Enalapril Maleate
   Esomeprazole Magnesium
   Famotidine
   Fexofenadine HCl
   Fluconazole
   Fluoxetine HCl
   Galantamine HBr
   Ibuprofen
   Lacidipine
   Lamotrigine
   Lansoprazole
   Levetiracetam
   Levo Cetirizine
   Levofloxacin
   Loratadine
   Losartan Potassium
 
   

delivering world-class generics

 




Domperidone Maleate
CAS number 99497-03-7

Structure Formula :

Identification

Synonyms 5-Chloro-1-[1-[3-(2-oxo-1,3-dihydrobenzoimidazol-1-yl)propyl]-4-piperidyl]-1,3-dihydrobenzoimidazol-2-one maleate
Molecular Structure Domperidone maleate, 5-Chloro-1-[1-[3-(2-oxo-1,3-dihydrobenzoimidazol-1-yl)propyl]-4-piperidyl]-1,3-dihydrobenzoimidazol-2-one maleate,

CAS Registry Number 99497-03-7
Molecular Formula C22H24ClN5O2.C4H4O4
Molecular Weight 541.99
Appearance: White or almost white powder
Use: Digestive system drugs
Standard: BP/USP/CP
Package: 25KG/Drum

Description

Domperidone is a peripheral dopamine antagonist structurally related to the butyrophenones with antiemetic and gastroprokinetic properties.

Domperidone effectively increases esophageal peristalsis and lower esophageal sphincter pressure (LESP), increases gastric motility and peristalsis, enhances gastroduodenal coordination and consequently facilitates gastric emptying and decreases small bowel transit time.

The mechanism of action of domperidone is related to its peripheral dopamine receptor blocking properties. Emesis induced by apomorphine, hydergine, morphine or levodopa through stimulation of the chemoreceptor trigger zone (situated outside the blood-brain barrier) can be blocked by domperidone. There is indirect evidence that emesis is also inhibited at the gastric level, since domperidone also inhibits emesis induced by oral levodopa, and local gastric wall concentrations following oral domperidone are much greater than those of the plasma and other organs. Domperidone does not readily cross the blood-brain barrier and therefore is not expected to have central effects.

Domperidone elevates serum prolactin levels but has no effect on circulating aldosterone levels.

Warnings

In Clinical States: Dopamine receptor blocking agents elevate prolactin levels; the elevation persists during chronic administration. Tissue culture experiments indicate that approximately one-third of human breast cancers are prolactin dependent in vitro, a factor of potential importance if the prescription of these drugs is contemplated in a patient with previously detected breast cancer. Although disturbances such as galactorrhea, amenorrhea, gynecomastia, and impotence have been reported, the clinical significance of elevated serum prolactin levels is unknown for most patients. An increase in mammary neoplasms has been found in rodents after chronic administration of dopamine receptor blocking agents. Neither clinical studies nor epidemiologic studies conducted to date, however, have shown an association between chronic administration of these drugs and mammary tumorigenesis. The available evidence is considered too limited to be conclusive at this time.

Precautions

In the event that the patient develops galactorrhea and/or gynecomastia, withdrawal of the drug will result in alleviation of these symptoms.

Drug Interactions

The concomitant administration of anticholinergic drugs may compromise the beneficial effects of domperidone.
Since domperidone enhances gastric and small intestinal motility, it may accelerate absorption of drugs from the small bowel while slowing absorption of drugs taken up from the stomach, particularly those with sustained-release or enteric-coated formulations.

Care should be exercised when domperidone is administered in combination with MAO inhibitors.

The concomitant administration of domperidone maleate with antacids or H2-receptor blockers does not decrease the absorption of domperidone.

Dosage And Administration

Upper Gastrointestinal Motility Disorders: The usual dosage in adults is 10 mg orally 3 to 4 times a day, 15 to 30 minutes before meals and at bedtime if required. In severe or resistant cases the dose may be increased to a maximum of 20 mg 3 to 4 times a day.

Nausea and Vomiting Associated with Dopamine Agonist Antiparkinsonian Agents: The usual dosage in adults is 20 mg orally 3 to 4 times a day. Higher doses may be required to achieve symptom control while titration of the antiparkinsonian medication is occurring.
 
 
PDF DOWNLOAD WORD DOCUMENT
 
   Chemicals
   Ethanol
   Phenyl acetic acid
   3,4-methylenedioxyphenyl-2-propanone
   Pseudoephedrine
   Piperidine
   Methylamine
   Propionic anhydride
   Para Methoxy Phenyl Acetone
   Para Methoxy Phenyl Acetic Acid
   Raspberry Ketone
   Benzyl Acetone
   Tyramine
   Biphenyl (Phenyl benzene)
   1-phenyl-1-hexanone
   Benzene
   Benzyl methyl ketone
   Bromo phenyl acetone (1-Bromo-1-phenyl-2-propanone)
   3'-Aminoacetophenone
   3'-Chloroacetophenone
   Toluene
   Denatonium Benzoate
   Anthranilic acid
   Ephedrine
   Ergonovine
   Ergotamine
   Hydroiodic
   Norpseudoephedrine
   Phenylpropanolamine
   Phosphorus
   Benzaldehyde
   Nitroethane
   Gamma butyrolactone
   N-Phenethyl-4-piperidinone
   Methylamine
   Ethylamine
   Isosafrole
   Safrole
   Piperonal
   N-methylephedrine
   N-methylpseudoephedrine
   Acetic anhydride
   Diethyl ether
   Potassium permanganate
   2-butanone
   Toluene
   Potassium permanganate
   2-butanone
   Methyl isobutyl ketone
   Hydrochloric acid
   Para Anisyl Choride
   Para Anisic Acid
   Para Anisyl Bromide
   Para Anisoyl Acetone
   Methyl Tyramine
   Tyramine
   Para Cresyl Acetate
   Para Cresyl Methyl Ether
   Anisyl Formate
   Ortho Anisic Aldehyde
   3-Aminopropyl Imidazole
   3-Benzyloxy Propionitrile
   1-Hydroxy Cyclohexyl-4-Methoxyphenylacetonitrile
   Veratrol
   Manganese Sulphate Monohydrate
   Pharmaceuticals API
   Rabeprazole Sodium
   Ramipril
   Ranitidine Hydrochloride
   Risperidone
   Rivastigmine Tartrate
   Rizatriptan 
   Rosiglitazone Maleate
   Sevelamer hydrochloride
   Telmisartan
   Tamsulosin HCl
   Tegaserod Maleate
   Terbinafine HCl
   Testosterone
   Tolterodine Tartrate
   Trandolapril 
   Montelukast Sodium
   Moxifloxacin HCl
   Naproxen
   Naratriptan
   Norfloxacin
   Nizatidine
   Nandrolone Decanoate
   Olmesartan
    Omeprazole
   Omeprazole Sodium
   Oxaprozin
   Paroxetine
   Pantoprazole Sodium
   Primidone
   Quetiapine Fumarate
   Quinine Sulfate
   Metoprolol Succinate
   Valdecoxib
   Valsartan
   Venlafaxine
   Voriconazole
   Zolmitriptan 
   Zonisamide
   Betalactams Piperacillin
   Tazobactam
   Meropenem
   Cefalexin
   Cefradine
   Cefadroxil
   Cefprozil
   Cefixime
   Ceftibuten
   Cefditoren Pivoxil
   Cefazolin Sodium
   Cefuroxime Sodium
   Cefoxitin Sodium
   Cefotetan Sodium
   Cefotaxime Sodium
   Cefoperazone Sodium
   Ceftizoxime Sodium

 

 

Home Page Company Profile Our Products     Amlodpine Besylates     Atorvastatin Calcium     Caffeine     Clopidogrel Bisulfate     Clomipramine HCL     Losartan Potassium     Metformin Hcl     Nandrolone Decanoate     Pantoprazole Sodium     Pseudoephedrine Hydrochloride     Quinine Sulfate     Ramipril     Ranitidine Hydrochloride     Sertraline Hcl     Sevelamer Hydrochloride     Sodium Valproate     Testosterone     Theophyline     Valsartan     Toluene     Benzyl Chloride     Ethanol     Modafinil     Para Methoxy Phenyl Acetone     Anthranilic Acid

Copyright © Taj Pharmaceuticals Ltd. | Privacy Policy | Terms & Conditions |
Sitemap

   
 

© 2004 - 2019 Taj Pharmaceuticals Limited . All rights reserved
Active Pharmaceutical Ingredients manufacturer, exporter, drug ingredients, pharmaceuticals, India
Note:-We are committed to helping you find the right answers to your questions and concerns. However, this web site is not intended to give investment advice, promote the use of Taj Pharmaceuticals  Ltd products or provide information on which to base medical treatment. If you have questions regarding any Taj Pharmaceuticals  Ltd product or are experiencing a medical emergency, please consult your health care provider.
Additionally, contact information on this web site cannot be used to report adverse drug events. If you are a physician, please follow the procedures required by your country's regulations. Please choose one of the given options to contact us and we will respond to your inquiry as quickly as possible.