|
(l)-Etafedrine Hydrochloride
 |
Molecular Formula : C12H19NO.HCl
Molecular Weight : 229.75
CAS No. : [5591-29-7]
Chemical Name :
1. (1R,2S)-2-[Ethyl (methyl)amino]-1-phenylpropan-1-ol
Hydrochloride.
2. (1R,2S)-2-Ethylmethylamino-1-phenyl-1-propanol Hydrochloride
Specifications : |
| 1. |
Description : |
White to off white
crystalline powder |
| 2. |
Identification: |
Infrared spectrum of sample is
concordant with standard. |
| 3. |
Melting range : |
183° - 186°C |
| 4. |
Specific rotation : |
- 17.5° - 19.5° (5 % solution in
water) |
| 5. |
Moisture content : |
Not more than 0.5 % w/w |
| 6. |
Sulphated ash : |
Not more than 0.1 % w/w |
| 7. |
Assay (Non.Aq. Titration)
: |
Between 99.0 and 100.5 % w/w
(dried basis) |
Therapeutic indications : Bronchodilator
Packing : Packed in double lined
polyethylene bags in 10 kg
/ 25 kg fiber drums.
Storage : Store below 35°C
IUPAC Name:
2-[ethyl(methyl)amino]-1-phenylpropan-1-ol hydrochloride
CAS Registry Number: 5591-29-7
Synonyms: Nethamine, Nethaphyl, Etafedrine hydrochloride,
Nethamine (TN), Etafedrine hydrochloride (USAN), Etafedrine
hydrochloride [USAN], CID68646, EINECS 227-000-5, D04072,
alpha-(1-(Ethylmethylamino)ethyl)benzyl alcohol hydrochloride,
Benzenemethanol, alpha-(1-(ethylmethylamino)ethyl)-, hydrochloride,
5591-29-7, BENZYL ALCOHOL, alpha-(1-(ETHYLMETHYLAMINO)ETHYL)-,
HYDROCHLORIDE, (-)-, 530-35-8, 7681-79-0
Molecular Formula: C12H20ClNO
Molecular Weight: 229.746300 [g/mol]
H-Bond Donor: 2 H-Bond Acceptor: 2
Etafedrine were studied on the tracheal chain preparation and the
atria of the guinea pig and on the rabbit perfused heart.
Contraction of the tracheal chain by acetylcholine or histamine was
antagonized by epinephrine (adrenaline), etafedrine and ephedrine, the
relative potencies being 91:1:0.3, respectively.
Propranolol (5 X 10(-7) mol/l) completely antagonized the bronchodilator
effect of 10(-4) mol/l etafedrine on the acetylcholine-evoked
contraction. Etafedrine up to 3 X 10(-4) mol/l did not increase heart
rate or force of contraction in guinea pig atria. In contrast to
tyramine and ephedrine (both 10(-5) mol/l), etafedrine (10(-4) mol/l)
failed to release 3H-norepinephrine (noradrenaline) in the perfused
rabbit heart. Moreover, the concentration-dependent positive
chronotropic and inotropic effects of norepinephrine in isolated atria
were slightly, but not significantly enhanced by etafedrine.
It is concluded that N-ethylation of ephedrine suppresses the indirect
sympathomimetic activity and markedly enhances the efficacy on beta
2-adrenoceptors.
Etafedrine appears to be a sympathomimetic agent with a selective
activity on beta 2-adrenoceptors.
PHARMACOLOGICAL ACTION:
Etafedrine a sympathomimetic agent, acts on the sympathetic
receptors of the bronchial tree relaxing spasm in a manner similar to
that of ephedrine.
It helps to control cough associated with inflammation of the mouth and
throat that is not helped by cough medications that are less strong.
Hydrocodone is a narcotic medication that is an antitussive (cough
suppressant). It helps to reduce cough by affecting the cough centre in
the brain.
Etafedrine belongs to the family of medications called decongestants. It
works by narrowing blood vessels in the nasal passages, helping to
relieve nasal stuffiness.
Do not give this medication to anyone else, even if they have the same
symptoms as you do. It can be harmful for people to take this medication
if their doctor has not prescribed it.
The recommended dose of this medication is
Adults: 5 mL (1 teaspoonful) every 3 to 5 hours as needed, but not more
than 30 mL in any 24-hour period.
Children 6 to 12 years of age: 2.5 mL to 5 mL every 3 to 5 hours as
needed to a maximum of 15 mL in any 24-hour period.
Children 1 to 6 years of age: 1.25 mL to 2.5 mL every 3 to 5 hours as
needed to a maximum of 3 doses in any 24-hour period.
Use an oral syringe to measure each dose of the liquid as it gives a
more accurate measurement than household teaspoons.
Store this medication at room temperature, protect it from light, and
keep it out of the reach of children.
Do not dispose of medications in wastewater (e.g. down the sink or in
the toilet) or in household garbage. Ask your pharmacist how to dispose
of medications that are no longer needed or have expired.
Side effects occur
* fast, slow, or pounding heartbeat
* hallucinations (seeing, hearing, or feeling things that are not there)
* hives, itching, or skin rash
* increased sweating
* irregular breathing
* mental depression or other mood or mental changes
* redness or flushing of face
* ringing or buzzing in the ears
* shortness of breath, wheezing, or troubled breathing
* swelling of face
* trembling or uncontrolled muscle movements
* unusual excitement or restlessness (especially in children)
Stop taking the medication and seek immediate medical attention if
any of the following occur:
* cold, clammy skin
* headache (severe or continuing)
* low blood pressure
* pinpoint pupils of eyes
* seizures
* severe confusion or disorientation
* severe dizziness
* severe drowsiness
* severe nausea or vomiting
* severe nervousness or restlessness
* severe weakness
* shortness of breath or troubled breathing (severe or continuing)
* signs of a severe allergic reaction such as hives; difficulty
breathing; swelling of the tongue, face, mouth, or throat
* slow heartbeat
Etafedrine (INN) or ethylephedrine is a long-acting bronchodilator
and has the brand name Nethaprin. It is commercially available as both
the free base, and as the hydrochloride.
Ethylephedrine may be synthesized by alkylating ephedrine with ethyl
iodide. The hydrochloride may be prepared by passing hydrogen chloride
through a solution of ethylephedrine in diethyl ether.
 Note:
These API/ chemicals are designated as
those that are used in the manufacture of the controlled substances and
are important to the manufacture of the substances. For any (Control
Substance) products Import and Export *** subjected to your country
government laws /control substance ACT.
Note /Government Notification:
These chemicals are designated as those that are used in the manufacture
of the controlled substances and are important to the manufacture of the
substances. For any (Control Substance) products Import and Export ***
subjected to your country government laws /control substance ACT.
Information: The information on this web page is provided to help you
to work safely, but it is intended to be an overview of hazards, not a
replacement for a full Material Safety Data Sheet (MSDS). MSDS forms can
be downloaded from the web sites of many chemical suppliers. ,also that
the information on the PTCL Safety web site, where this page was hosted,
has been copied onto many other sites, often without permission. If you
have any doubts about the veracity of the information that you are
viewing, or have any queries, please check the URL that your web browser
displays for this page. If the URL begins "www.tajapi.com/www/Denatonium
Benzoate.htm/" the page is maintained by the Safety Officer in Physical
Chemistry at Oxford University. If not, this page is a copy made by some
other person and we have no responsibility for it.
The Controlled Substances Act (CSA) was enacted into law by the Congress
of the United States as Title II of the Comprehensive Drug Abuse
Prevention and Control Act of 1970.[1] The CSA is the federal U.S. drug
policy under which the manufacture, importation, possession, use and
distribution of certain substances is regulated. The Act also served as
the national implementing legislation for the Single Convention on
Narcotic Drugs.
|
|
India
