Welcome To Taj Active Pharmaceuticals Ingredients & Chemicals (api) Taj Pharmaceuticals Limited (Manufacturers) India
    About Worldwide  |     FAQs    |    Careers    |        Media Center  |    Taj Pharmaceuticals  World   |    TAJ Group
    Taj Active Pharmaceuticals Ingredients & Chemicals (api) Taj Pharmaceuticals Limited

chemicals suppliers

      India              Latin America/ Caribbean            Africa & Middle East              Asia              Russia              Europe  

Active Pharmaceutical Ingredients  TAJ PHARMACEUTICALS LIMITED  

Home    API   Pharmaceuticals API List    Chemicals    Manufacturing     Product Development    Product Search    Agro Chemicals
  Custom Pharma Services      Contact Us

BP - British Pharmacopoeia CP - Chinese Pharmacopoeia EP - European Pharmacopoeia JP - Japanese Pharmacopoeia USP - United States Pharmacopoeia
***
Product exploitation, including development, sales and offer for sale are performed where permissible by patent law. This presentation is not and should not constitute as an offer for sale in territories where it is not permitted by law.

Thebaine manufacturers India exporter cas No. 115-37-7 Thebaine  suppliers from india companies Pharmaceuticals Drug from India Largest manufacturer Top Thebaine import india Thebaine export india Thebaine buyer india Thebaine seller India IP BP USP EP Thebaine Raw material manufacturer india Thebaine dealers india Thebaine producer india Thebaine API Active pharmaceuticals ingradients  Purchase Cheap Lowest Price COA MSDS certificate of Analysis wholesalers india Thebaine suppliers india Thebaine trader Drug india Thebaine purchase india Thebaine structure Thebaine benefits Thebaine pharmacy and drugs review api Thebaine  active pharmaceutical ingredients suppliers pharmaceutical manufacturing pharmaceutical drugs pharmaceutical intermediates pharmaceutical chemicals pharmaceutical raw materials active pharmaceutical ingredients committee active pharmaceutical ingredients manufacturer construction chemicals manufacturers manufacturers of industrial chemicals chemicals suppliers chemicals Thebaine  offers chemicals wholesalers exporters chemicals specialty chemicals chemicals Thebaines indian chemical suppliers chemicals india company  Indian chemical manufacturers association chemical industries in India indian chemical company chemical factories india safety Thebaines manufacturers India plastic Thebaines manufacturers India definition of Thebaine Thebaine  synthesis Thebaine  salt effects of Thebaine clinical advantage of Thebaine polymorphs of Thebaine preparation of Thebaine efficacy of Thebaine beneficial effects of Thebaine determination and validation of Thebaine determination Thebaine Thebaine -Thebaine side effect of Thebaine polymorphs of Thebaine level of Thebaine Thebaine process for preparing Thebaine Thebaine mg process for Thebaine detailed info for Thebaine catalog Thebaine polymorphs of Thebaine dosage of Thebaine intermediate of Thebaine Thebaine powder supply Thebaine Taj Pharmaceuticals Limited.

 

 Taj Active Pharmaceuticals Ingredients & Chemicals

   Bulk Drugs Pharmaceuticals
   Chemicals
   Oseltamivir Phosphate
   Phenyl Propanolamine
   Phenylephrine
   Etafedrine
   Theophylline
   Tramadol
   Methylphenidate
   Morphine HCl
   Morphine sulphate
   Ephedrine (EPH)
   Pseudoephedrine hydrochloride
   Codeine base
   Codeine phosphate hemihydrate
   Zolpidem Tartrate
   Caffeine
   Gabapentin
   Gemcitabine
   Glimepiride
   Granisetron Hcl
   Ibandronate Sodium
   Imatinib Mesylate
   Irbesartan
   Irinotecan Hcl
   Isradipine
   Lamotrigine
   Lercanidipine Hcl
   Letrozole
   Losartan Potassium
   Loteprednol Etabonate
   Magnesium Valproate
   Meloxicam
   Memantine Hcl
   Mesalazine
   Metamizol Magnesium
   Metaxalone
   Metformin Hcl
   Metoprolol Tartrate
   Mifepristone
   Mirtazapine
   Modafinil
   Mometasone Furoate
   Naltrexone Hcl
   Netaglinide
   Octreotide Acetate
   Olanzapine
   Ondansetron Base
   Ondansetron Hcl
   Oxaliplatin
   Oxcarbazepine
   Oxethazaine
   Pamidronate Disodium
   Pentoxifylline
   Perindopril
   Pioglitazone
   PiroxicamBetacyclodextrine
   Raloxifene Hcl
   Repaglinide
   Rivastigmine Tartrate
   Ropinirole
   Sertraline Hcl
   Sodium Valproate
   Sildenafil Citrate
   Sumatriptan Succinate
   Temozolomide
   Terlipressin
   Testosterone
   Tiagabine Hcl
   Tizanidine Hcl
   Topiramate
   Tramadol Hcl
   Valproic Acid
   Venlafaxine Hcl
   Ziprasidone Hcl
   Zoledronic Acid
   Acenocoumarol
   Aluminium-magnesium-hydroxy-carbonate-hexahydrate
   Buprenorphine HCl
   Dihydrocodeine hydrogentartrate
   Ethylmorphine HCl
   Glibornuride
   Hydroxychloroquine sulphate
   Noroxymorphone
   Noscapine base
   Oxycodone
   Oxymorphone
   Phenobarbital acid
   Phenobarbital sodium
   Thebaine
   Pharmaceuticals API
   Alfuzosin
   Amlodipine Besylate
    Aripiprazole
   Atorvastatin Calcium
   Caffeine
   Candesartan Cilaxetil
   Cefdinir
   Cetirizine Dihydrochloride
   Ciprofloxacin HCl
   Dextromethorphan Base
   Diltiazem HCl
   Domperidone Base
   Domperidone Maleate
   Doxazosin Mesylate
   Duloxetine HCl
   Dutasteride
   Enalapril Maleate
   Esomeprazole Magnesium
   Famotidine
   Fexofenadine HCl
   Fluconazole
   Fluoxetine HCl
   Galantamine HBr
   Ibuprofen
   Lacidipine
   Lamotrigine
   Lansoprazole
   Levetiracetam
   Levo Cetirizine
   Levofloxacin
   Loratadine
   Losartan Potassium
 
   

delivering world-class generics

 

Thebaine CAS number 115-37-7

OTHER INFORMATION
Thebaine
CAS number 115-37-7

The consumption of poppy seeds in various foods may lead to a positive opiate result in urine subjected to testing for drugs of abuse. As a natural constituent of poppy seeds, thebaine was investigated as a possible marker for poppy seed consumption. Poppy seeds were examined for opiate content by gas chromatography-ion trap mass spectrometry (GC-MS) after extraction with methanol. Urine samples spiked with thebaine and urine from subjects given 11 g of poppy seeds were tested for the presence of thebaine, codeine, and morphine. Street heroin, one morphine and one codeine tablet, and urine from individuals who had used heroin were also examined for thebaine. Urine specimens were screened by enzyme immunoassay (EMIT) and confirmed for thebaine by GC-MS using a solid-phase extraction method. The GC-MS assay showed a linear response over a range of 1-100 ng/mL and a limit of detection of 0.5 ng/mL. Thebaine was detectable in the urine of poppy seed eaters in concentrations ranging from 2 to 81 ng/mL. Because thebaine was absent in powdered drugs and the urine of true opiate drug users, thebaine is proposed as a direct marker for poppy seed use.

The 14-hydroxymorphinans, such as, oxycodone, naloxone, naltrexone, nalbuphine and nalmefene are important opiate derivatives due to their behavior as potent analgesics and/or narcotic antagonists. The most practical synthetic routes to the preparation of these pharmaceuticals have utilized the alkaloid, thebaine, as a starting material. Other important opiate derivatives such as the ring-C bridged compounds buprenorp ine and etorphine are also most practically prepared from thebaine.

In accordance with one conventional process, thebaine is oxidized to 14-hydroxycodeinone by use of m-chloroperbenzoic acid in an acetic acid trifluoroacetic acid mixture or by a mixture of hydrogen peroxide and formic acid. 14-hydroxycodeinone is catalytically reduced to oxycodone. Oxycodone is a product sold for use as and analgesic and its production consumes large amounts of thebaine.

Oxycodone can be, in turn, O-demethylated with boron tribromide to yield oxymorphone. After blocking of the hydroxyl groups with a suitable blocking agent, such as, acetyl groups, the oxymorphone derivative is reacted with cyanogen bromide in a von Braun demethylation to yield an N-cyanodihydronormorphinone derivative that is thereafter hydrolyzed to 14-hydroxydihydronormorphinone (noroxymorphone). Noroxymoiphone can be readily converted to nal-compounds by N-alkylation with appropriate alkyl halide, or acylation with appropriate acyl halide or anhydrde, followed by reduction. A more generally applicable process, converts the oxycodone of the above process to noroxycodone by the von Braun N-dethylation followed by conversion to a 3-O-methyl-nal-compound using Na-kylation with an appropriate alkyl halide, or by alkylation with an appropnate alkyl halide, or acylation with appropriate acyl halide or anhydride, followed by reduction. The 3-O-methyl-nal-compound is reacted to a nal-compound by O-demethylation.

One reason for the limited availability of thebaine, and its high cost, is that total synthesis is difficult. U.S. Pat. Nos. 4,613,668 and 4,795,813 discuss the scarcity of thebaine and teach the total synthesis, or alternative synthesis, of the 14-hydroxymorphinans. Yet, the demand for thebaine remains.

A second reason for the limited availability of thebaine, and its high cost, is that the primary source of thebaine is extraction from the poppy plant, Papaver somniferum. Morphine is the major alkaloid that accumulates in capsules of Papaver somniferum. Thus, the supply of thebaine is to a great degree limited to some fraction of the demand for morphine.

Further synthetic routes to the preparation of the 14-hydroxymorphinans are known using the alkaloid, oripavine, as a starting material.

Oripavine has not been used as a starting material for the 14-hydroxymorphinans in any practical sense because it is not recoverable from Papaver somiferum in any practical yield. Thus, there is now no real shortage of this material, but only because there has never developed any demand for it.

Information Associated with Product:
DRUG DESCRIPTION
OTHER INFORMATION >>
 
 
PDF DOWNLOAD WORD DOCUMENT
Product Enquiry Product Quotation Sample Request Place Your Order  
Product Enquiry Product Quotation Sample Request Place Your Order  
 
   Chemicals
   Ethanol
   Phenyl acetic acid
   3,4-methylenedioxyphenyl-2-propanone
   Pseudoephedrine
   Piperidine
   Methylamine
   Propionic anhydride
   Para Methoxy Phenyl Acetone
   Para Methoxy Phenyl Acetic Acid
   Raspberry Ketone
   Benzyl Acetone
   Tyramine
   Biphenyl (Phenyl benzene)
   1-phenyl-1-hexanone
   Benzene
   Benzyl methyl ketone
   Bromo phenyl acetone (1-Bromo-1-phenyl-2-propanone)
   3'-Aminoacetophenone
   3'-Chloroacetophenone
   Toluene
   Denatonium Benzoate
   Anthranilic acid
   Ephedrine
   Ergonovine
   Ergotamine
   Hydroiodic
   Norpseudoephedrine
   Phenylpropanolamine
   Phosphorus
   Benzaldehyde
   Nitroethane
   Gamma butyrolactone
   N-Phenethyl-4-piperidinone
   Methylamine
   Ethylamine
   Isosafrole
   Safrole
   Piperonal
   N-methylephedrine
   N-methylpseudoephedrine
   Acetic anhydride
   Diethyl ether
   Potassium permanganate
   2-butanone
   Toluene
   Potassium permanganate
   2-butanone
   Methyl isobutyl ketone
   Hydrochloric acid
   Para Anisyl Choride
   Para Anisic Acid
   Para Anisyl Bromide
   Para Anisoyl Acetone
   Methyl Tyramine
   Tyramine
   Para Cresyl Acetate
   Para Cresyl Methyl Ether
   Anisyl Formate
   Ortho Anisic Aldehyde
   3-Aminopropyl Imidazole
   3-Benzyloxy Propionitrile
   1-Hydroxy Cyclohexyl-4-Methoxyphenylacetonitrile
   Veratrol
   Manganese Sulphate Monohydrate
   Pharmaceuticals API
   Rabeprazole Sodium
   Ramipril
   Ranitidine Hydrochloride
   Risperidone
   Rivastigmine Tartrate
   Rizatriptan 
   Rosiglitazone Maleate
   Sevelamer hydrochloride
   Telmisartan
   Tamsulosin HCl
   Tegaserod Maleate
   Terbinafine HCl
   Testosterone
   Tolterodine Tartrate
   Trandolapril 
   Montelukast Sodium
   Moxifloxacin HCl
   Naproxen
   Naratriptan
   Norfloxacin
   Nizatidine
   Nandrolone Decanoate
   Olmesartan
    Omeprazole
   Omeprazole Sodium
   Oxaprozin
   Paroxetine
   Pantoprazole Sodium
   Primidone
   Quetiapine Fumarate
   Quinine Sulfate
   Metoprolol Succinate
   Valdecoxib
   Valsartan
   Venlafaxine
   Voriconazole
   Zolmitriptan 
   Zonisamide
   Betalactams Piperacillin
   Tazobactam
   Meropenem
   Cefalexin
   Cefradine
   Cefadroxil
   Cefprozil
   Cefixime
   Ceftibuten
   Cefditoren Pivoxil
   Cefazolin Sodium
   Cefuroxime Sodium
   Cefoxitin Sodium
   Cefotetan Sodium
   Cefotaxime Sodium
   Cefoperazone Sodium
   Ceftizoxime Sodium

 

 

Home Page Company Profile Our Products     Amlodpine Besylates     Atorvastatin Calcium     Caffeine     Clopidogrel Bisulfate     Clomipramine HCL     Losartan Potassium     Metformin Hcl     Nandrolone Decanoate     Pantoprazole Sodium     Pseudoephedrine Hydrochloride     Quinine Sulfate     Ramipril     Ranitidine Hydrochloride     Sertraline Hcl     Sevelamer Hydrochloride     Sodium Valproate     Testosterone     Theophyline     Valsartan     Toluene     Benzyl Chloride     Ethanol     Modafinil     Para Methoxy Phenyl Acetone     Anthranilic Acid

Copyright © Taj Pharmaceuticals Ltd. | Privacy Policy | Terms & Conditions |
Sitemap

   
 

© 2004 - 2019 Taj Pharmaceuticals Limited . All rights reserved
Active Pharmaceutical Ingredients manufacturer, exporter, drug ingredients, pharmaceuticals, India
Note:-We are committed to helping you find the right answers to your questions and concerns. However, this web site is not intended to give investment advice, promote the use of Taj Pharmaceuticals  Ltd products or provide information on which to base medical treatment. If you have questions regarding any Taj Pharmaceuticals  Ltd product or are experiencing a medical emergency, please consult your health care provider.
Additionally, contact information on this web site cannot be used to report adverse drug events. If you are a physician, please follow the procedures required by your country's regulations. Please choose one of the given options to contact us and we will respond to your inquiry as quickly as possible.