Welcome To Taj Active Pharmaceuticals Ingredients & Chemicals (api) Taj Pharmaceuticals Limited (Manufacturers) India
    About Worldwide  |     FAQs    |    Careers    |        Media Center  |    Taj Pharmaceuticals  World   |    TAJ Group
    Taj Active Pharmaceuticals Ingredients & Chemicals (api) Taj Pharmaceuticals Limited

chemicals suppliers

      India              Latin America/ Caribbean            Africa & Middle East              Asia              Russia              Europe  

Active Pharmaceutical Ingredients  TAJ PHARMACEUTICALS LIMITED  

Home    API   Pharmaceuticals API List    Chemicals    Manufacturing     Product Development    Product Search    Agro Chemicals
  Custom Pharma Services      Contact Us

BP - British Pharmacopoeia CP - Chinese Pharmacopoeia EP - European Pharmacopoeia JP - Japanese Pharmacopoeia USP - United States Pharmacopoeia
***
Product exploitation, including development, sales and offer for sale are performed where permissible by patent law. This presentation is not and should not constitute as an offer for sale in territories where it is not permitted by law.

Theophylline manufacturers India exporter cas No. 58-55-9 Theophylline  suppliers from india companies Pharmaceuticals Drug from India Largest manufacturer Top Theophylline import india Theophylline export india Theophylline buyer india Theophylline seller India IP BP USP EP Theophylline Raw material manufacturer india Theophylline dealers india Theophylline producer india Theophylline API Active pharmaceuticals ingradients  Purchase Cheap Lowest Price COA MSDS certificate of Analysis wholesalers india Theophylline suppliers india Theophylline trader Drug india Theophylline purchase india Theophylline structure Theophylline benefits Theophylline pharmacy and drugs review api Theophylline  active pharmaceutical ingredients suppliers pharmaceutical manufacturing pharmaceutical drugs pharmaceutical intermediates pharmaceutical chemicals pharmaceutical raw materials active pharmaceutical ingredients committee active pharmaceutical ingredients manufacturer construction chemicals manufacturers manufacturers of industrial chemicals chemicals suppliers chemicals Theophylline  offers chemicals wholesalers exporters chemicals specialty chemicals chemicals Theophyllines indian chemical suppliers chemicals india company  Indian chemical manufacturers association chemical industries in India indian chemical company chemical factories india safety Theophyllines manufacturers India plastic Theophyllines manufacturers India definition of Theophylline Theophylline  synthesis Theophylline  salt effects of Theophylline clinical advantage of Theophylline polymorphs of Theophylline preparation of Theophylline efficacy of Theophylline beneficial effects of Theophylline determination and validation of Theophylline determination Theophylline Theophylline -Theophylline side effect of Theophylline polymorphs of Theophylline level of Theophylline Theophylline process for preparing Theophylline Theophylline mg process for Theophylline detailed info for Theophylline catalog Theophylline polymorphs of Theophylline dosage of Theophylline intermediate of Theophylline Theophylline powder supply Theophylline Taj Pharmaceuticals Limited.

 

 Taj Active Pharmaceuticals Ingredients & Chemicals

   Bulk Drugs Pharmaceuticals
   Chemicals
   Oseltamivir Phosphate
   Phenyl Propanolamine
   Phenylephrine
   Etafedrine
   Theophylline
   Tramadol
   Methylphenidate
   Morphine HCl
   Morphine sulphate
   Ephedrine (EPH)
   Pseudoephedrine hydrochloride
   Codeine base
   Codeine phosphate hemihydrate
   Zolpidem Tartrate
   Caffeine
   Gabapentin
   Gemcitabine
   Glimepiride
   Granisetron Hcl
   Ibandronate Sodium
   Imatinib Mesylate
   Irbesartan
   Irinotecan Hcl
   Isradipine
   Lamotrigine
   Lercanidipine Hcl
   Letrozole
   Losartan Potassium
   Loteprednol Etabonate
   Magnesium Valproate
   Meloxicam
   Memantine Hcl
   Mesalazine
   Metamizol Magnesium
   Metaxalone
   Metformin Hcl
   Metoprolol Tartrate
   Mifepristone
   Mirtazapine
   Modafinil
   Mometasone Furoate
   Naltrexone Hcl
   Netaglinide
   Octreotide Acetate
   Olanzapine
   Ondansetron Base
   Ondansetron Hcl
   Oxaliplatin
   Oxcarbazepine
   Oxethazaine
   Pamidronate Disodium
   Pentoxifylline
   Perindopril
   Pioglitazone
   PiroxicamBetacyclodextrine
   Raloxifene Hcl
   Repaglinide
   Rivastigmine Tartrate
   Ropinirole
   Sertraline Hcl
   Sodium Valproate
   Sildenafil Citrate
   Sumatriptan Succinate
   Temozolomide
   Terlipressin
   Testosterone
   Tiagabine Hcl
   Tizanidine Hcl
   Topiramate
   Tramadol Hcl
   Valproic Acid
   Venlafaxine Hcl
   Ziprasidone Hcl
   Zoledronic Acid
   Acenocoumarol
   Aluminium-magnesium-hydroxy-carbonate-hexahydrate
   Buprenorphine HCl
   Dihydrocodeine hydrogentartrate
   Ethylmorphine HCl
   Glibornuride
   Hydroxychloroquine sulphate
   Noroxymorphone
   Noscapine base
   Oxycodone
   Oxymorphone
   Phenobarbital acid
   Phenobarbital sodium
   Thebaine
   Pharmaceuticals API
   Alfuzosin
   Amlodipine Besylate
    Aripiprazole
   Atorvastatin Calcium
   Caffeine
   Candesartan Cilaxetil
   Cefdinir
   Cetirizine Dihydrochloride
   Ciprofloxacin HCl
   Dextromethorphan Base
   Diltiazem HCl
   Domperidone Base
   Domperidone Maleate
   Doxazosin Mesylate
   Duloxetine HCl
   Dutasteride
   Enalapril Maleate
   Esomeprazole Magnesium
   Famotidine
   Fexofenadine HCl
   Fluconazole
   Fluoxetine HCl
   Galantamine HBr
   Ibuprofen
   Lacidipine
   Lamotrigine
   Lansoprazole
   Levetiracetam
   Levo Cetirizine
   Levofloxacin
   Loratadine
   Losartan Potassium
 
   

delivering world-class generics

 


Theophylline


 

 





Cas No. [58-55-9]

Leading manufacturers of Theophylline and its derivatives in India.

Name : Theophylline
CAS # : [58-55-9]
End Use : Bronchodilator

IUPAC Name: 1,3-dimethyl-7H-purine-2,6-dione | CAS Registry Number: 58-55-9
Synonyms: theophylline, Elixophyllin, Theophyllin, Theolair, Theocin, Nuelin, Synophylate, Bronkodyl, Aerolate, Theovent, Respbid, Theobid, Uniphyl, 1,3-Dimethylxanthine, Pseudotheophylline, aminophylline, Slo-phyllin, Elixophylline, Liquophylline, Armophylline

Molecular Formula: C7H8N4O2 Molecular Weight: 180.164020 [g/mol]
H-Bond Donor: 1 H-Bond Acceptor: 4


A methyl xanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central nervous system stimulant activities. Theophylline inhibits the 3',5'-CYCLIC NUCLEOTIDE PHOSPHODIESTERASE that degrades CYCLIC AMP thus potentiates the actions of agents that act through ADENYLATE CYCLASE and cyclic AM

DRUG CLASS AND MECHANISM: Theophylline belongs to a class of medications called bronchodilators, used in treating asthma and other airway diseases. Asthma is a breathing problem involving narrowing of the airways. Airways are breathing passages that allow air to move in and out of the lungs. Airways can be narrowed due to accumulation of mucus, spasm of the muscles that surround these airways, or swelling of the lining of the airways. Airway narrowing leads to symptoms of shortness of breath, wheezing, cough and congestion. The narrowed airways can open either spontaneously or from medications. Medications that open airways are called bronchodilators. Theophylline opens airways by relaxing the smooth muscles in the walls of the airways. Theophylline can also be helpful in patients with emphysema and chronic bronchitis when their symptoms are partially related to reversible airway narrowing. Theophylline also strengthens right heart function and diaphragm movement.

The main actions of theophylline involve:

           relaxing bronchial smooth muscle

           increasing heart muscle contractility and efficiency: positive inotropic

           increasing heart rate: positive chronotropic

           increasing blood pressure

           increasing renal blood flow

           some anti-inflammatory effects

           central nervous system stimulatory effect mainly on the medullary respiratory center.

 HistoryTheophylline

Theophylline was first extracted from tea leaves and chemically identified around 1888 by the German biologist Albrecht Kossel.Just seven years after its discovery, a chemical synthesis starting with 1,3-dimethyluric acid was described by Emil Fischer and Lorenz Ach. The Traube synthesis, an alternative method to synthesize Theophylline has been introduced in 1900 by another German scientist, Wilhelm Traube. Theophylline's first clinical use came in 1902 as diuretic.It took additional 20 years until its first description in asthma treatment.

Pharmacokinetics

Absorption

Bioavailability is 100%. However, taking the drug late in the evening may slow the absorption process, without affecting the bioavailability. Taking the drug after a meal high in fat content will also slow down the absorption process, without affecting the bioavailability.

Distribution

Theophylline is distributed in the extracellular fluid, in the placenta, in the mother's milk and in the central nervous system. The volume of distribution is 0.5 L/kg. The protein binding is 40%. The volume of distribution may increase in neonates and those suffering from cirrhosis or malnutrition, whereas the volume of distribution may decrease in those suffering from obesity.

Metabolism

Theophylline is metabolized extensively in the liver (up to 70%). It undergoes N-demethylation via cytochrome P450 1A2. It is metabolized by parallel first order and Michaelis-Menten pathways. Metabolism may become saturated (non-linear), even within the therapeutic range. Small dose increases may result in disproportionately large increases in serum concentration. Methylation in Theophylline is also important in the infant population. Smokers and people with hepatic (liver) impairment metabolize it differently.

Elimination

Theophylline is excreted unchanged in the urine (up to 10%). Clearance of the drug is increased in these conditions: children 1 to 12, teenagers 12 to 16, adult smokers, elderly smokers, cystic fibrosis, hyperthyroidism. Clearance of the drug is decreased in these conditions: elderly, acute congestive heart failure, cirrhosis, hypothyroidism and febrile viral illness.

The elimination half-life varies: 30 hours for premature neonates, 24 hours for neonates, 3.5 hours for children ages 1 to 9, 8 hours for adult non-smokers, 5 hours for adult smokers, 24 hours for those with hepatic impairment, 12 hours for those with congestive heart failure NYHA class I-II, 24 hours for those with congestive heart failure NYHA class III-IV, 12 hours for the elderly.

Indications

The main therapeutic uses of theophylline are aimed at:

           chronic obstructive pulmonary disease (COPD)

           asthma

           infant apnea

Uses Under Investigation

A clinical study reported in 2008 that theophylline was helpful in improving the sense of smell in study subjects with anosmia.

Side-effects

The use of theophylline is complicated by the fact that it interacts with various drugs, chiefly cimetidine and phenytoin, and that it has a narrow therapeutic index, so its use must be monitored to avoid toxicity. It can also cause nausea, diarrhea, increase in heart rate, arrhythmias, and CNS excitation (headaches, insomnia, irritability, dizziness and lightheadedness). Its toxicity is increased by erythromycin, cimetidine, and fluoroquinolones, such as "cipro" (ciprofloxacin). It can reach toxic levels when taken with fatty meals, an effect called dose dumping.



 

 
          text logo Material Safety Data Sheet  
  PDF DOWNLOAD      WORD DOCUMENT                TEXT DOCUMENT                         MSDS

 

Product Enquiry Product Quotation Sample Request Place Your Order Detail icon    
Product Enquiry Product Quotation Sample Request Place Your Order       Details
 
   Chemicals
   Ethanol
   Phenyl acetic acid
   3,4-methylenedioxyphenyl-2-propanone
   Pseudoephedrine
   Piperidine
   Methylamine
   Propionic anhydride
   Para Methoxy Phenyl Acetone
   Para Methoxy Phenyl Acetic Acid
   Raspberry Ketone
   Benzyl Acetone
   Tyramine
   Biphenyl (Phenyl benzene)
   1-phenyl-1-hexanone
   Benzene
   Benzyl methyl ketone
   Bromo phenyl acetone (1-Bromo-1-phenyl-2-propanone)
   3'-Aminoacetophenone
   3'-Chloroacetophenone
   Toluene
   Denatonium Benzoate
   Anthranilic acid
   Ephedrine
   Ergonovine
   Ergotamine
   Hydroiodic
   Norpseudoephedrine
   Phenylpropanolamine
   Phosphorus
   Benzaldehyde
   Nitroethane
   Gamma butyrolactone
   N-Phenethyl-4-piperidinone
   Methylamine
   Ethylamine
   Isosafrole
   Safrole
   Piperonal
   N-methylephedrine
   N-methylpseudoephedrine
   Acetic anhydride
   Diethyl ether
   Potassium permanganate
   2-butanone
   Toluene
   Potassium permanganate
   2-butanone
   Methyl isobutyl ketone
   Hydrochloric acid
   Para Anisyl Choride
   Para Anisic Acid
   Para Anisyl Bromide
   Para Anisoyl Acetone
   Methyl Tyramine
   Tyramine
   Para Cresyl Acetate
   Para Cresyl Methyl Ether
   Anisyl Formate
   Ortho Anisic Aldehyde
   3-Aminopropyl Imidazole
   3-Benzyloxy Propionitrile
   1-Hydroxy Cyclohexyl-4-Methoxyphenylacetonitrile
   Veratrol
   Manganese Sulphate Monohydrate
   Pharmaceuticals API
   Rabeprazole Sodium
   Ramipril
   Ranitidine Hydrochloride
   Risperidone
   Rivastigmine Tartrate
   Rizatriptan 
   Rosiglitazone Maleate
   Sevelamer hydrochloride
   Telmisartan
   Tamsulosin HCl
   Tegaserod Maleate
   Terbinafine HCl
   Testosterone
   Tolterodine Tartrate
   Trandolapril 
   Montelukast Sodium
   Moxifloxacin HCl
   Naproxen
   Naratriptan
   Norfloxacin
   Nizatidine
   Nandrolone Decanoate
   Olmesartan
    Omeprazole
   Omeprazole Sodium
   Oxaprozin
   Paroxetine
   Pantoprazole Sodium
   Primidone
   Quetiapine Fumarate
   Quinine Sulfate
   Metoprolol Succinate
   Valdecoxib
   Valsartan
   Venlafaxine
   Voriconazole
   Zolmitriptan 
   Zonisamide
   Betalactams Piperacillin
   Tazobactam
   Meropenem
   Cefalexin
   Cefradine
   Cefadroxil
   Cefprozil
   Cefixime
   Ceftibuten
   Cefditoren Pivoxil
   Cefazolin Sodium
   Cefuroxime Sodium
   Cefoxitin Sodium
   Cefotetan Sodium
   Cefotaxime Sodium
   Cefoperazone Sodium
   Ceftizoxime Sodium

 

 

Home Page Company Profile Our Products     Amlodpine Besylates     Atorvastatin Calcium     Caffeine     Clopidogrel Bisulfate     Clomipramine HCL     Losartan Potassium     Metformin Hcl     Nandrolone Decanoate     Pantoprazole Sodium     Pseudoephedrine Hydrochloride     Quinine Sulfate     Ramipril     Ranitidine Hydrochloride     Sertraline Hcl     Sevelamer Hydrochloride     Sodium Valproate     Testosterone     Theophyline     Valsartan     Toluene     Benzyl Chloride     Ethanol     Modafinil     Para Methoxy Phenyl Acetone     Anthranilic Acid

Copyright Taj Pharmaceuticals Ltd. | Privacy Policy | Terms & Conditions |
Sitemap

   
 

2004 - 2009 Taj Pharmaceuticals Limited . All rights reserved
Active Pharmaceutical Ingredients manufacturer, exporter, drug ingredients, pharmaceuticals, India
Note:-We are committed to helping you find the right answers to your questions and concerns. However, this web site is not intended to give investment advice, promote the use of Taj Pharmaceuticals  Ltd products or provide information on which to base medical treatment. If you have questions regarding any Taj Pharmaceuticals  Ltd product or are experiencing a medical emergency, please consult your health care provider.
Additionally, contact information on this web site cannot be used to report adverse drug events. If you are a physician, please follow the procedures required by your country's regulations. Please choose one of the given options to contact us and we will respond to your inquiry as quickly as possible.